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CONTENT
LIST OF FIGURES
ABBREVIATIONS
LIST OF ORIGINAL PUBLICATIONS
ABSTRACT
REVIEW OF THE LITERATURE
1 The Two Vascular Systems
2 The Cardiovascular System
3 Form and Function of the Lymphatic System
3.1 Drainage
3.2 Immune Defence
3.3 Intestinal Absorption
3.4 Lymph Formation
3.5 Lymph Propulsion
3.6 Pre-lymphatic Channels
4 Development of the Lymphatic System
4.1 Centrifugal Sprouting
4.2 Centripetal Sprouting
5 Lymphatics in Different Vertebrates
5.1 Fish
5.2 Amphibians and Reptiles
5.3 Birds and Mammals
6 Pathology
6.1 Blood Vessels and Lymphatic Vessels in Disease
6.2 Lymphedema
6.2.1 Hereditary Lymphedema Type I and II
6.2.2 Lymphedema-Distichiasis Syndrome
6.2.3 Lymphangiectasia
6.3 Lymphatic Neoplasms
6.4 Tumor Lymphangiogenesis
6.5 Therapeutic Lymphangiogenesis
7 VEGFs
7.1 VEGF - Master Effector of Angiogenesis
7.2 PlGF, VEGF-B and Other Problem Children
7.3 The Lymphangiogenic Factors: VEGF-C and VEGF-D
7.3.1 Molecular Features of VEGF-C and VEGF-D
7.3.2 Structure of VEGFR-3 and Its Ligands
7.3.3 VEGF-C Expression and Its Regulation
7.3.4 VEGF-C Signaling
OUTLINE OF THE STUDY
MATERIALS AND METHODS
RESULTS AND DISCUSSION
1 VEGF-C is Lymphangiogenic
2 Mature VEGF-C is Lymphangiogenic in the Chick CAM
3 VEGF-D is a Ligand for VEGFR-2 and VEGFR-3
4 Uncoupling of Receptor Binding from Specificity Allows to Create a Super-VEGF
ACKNOWLEDGEMENTS
REFERENCES
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